A study of the pepsin in the sputum for diagnosis and treatment evaluation of laryngopharyngeal reflux.
- Author:
Shukui YU
1
;
Yang CHEN
;
Jianhua QIU
;
Xiaona ZONG
;
Xiaodong CHENG
;
Feng PAN
;
Wenjuan MI
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, 710032, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Female;
Humans;
Laryngopharyngeal Reflux;
diagnosis;
therapy;
Male;
Middle Aged;
Pepsin A;
analysis;
Sputum;
chemistry;
Treatment Outcome;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(13):604-607
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the value of the pepsin in the sputum for diagnosing and evaluating the effectiveness of treatment of laryngopharyngeal reflux.
METHOD:Thirty-six patients with the symptoms of dry pharynx, globus pharyngeus, excessive throat clearing, chronic cough and so on were divided into laryngopharyngeal reflux group and chronic laryngitis group by the results of therapeutic trial taking proton pump inhibitors for 3 months. The estimation of the reflux symptom index (RSI), the reflux finding score (RFS) and the detection of pepsin in the sputum were done before and after the treatment. The difference between two groups and the value of the pepsin were analyzed.
RESULT:There were significant decreasing in RSI, RFS and pepsin level (P < 0.01) after the treatment in all patients. There were statistical differences between the laryngopharyngeal reflux group and the chronic laryngitis group in the changes of RSI and pepsin level (P < 0.01).
CONCLUSION:Pepsin level in the sputum might be used as a objective, effective method for diagnosing and evaluating the effectiveness in laryngopharyngeal reflux.
