Expressions of cyclin D1 and p16 in hypopharyngeal squamous cell carcinoma and their clinical significance.
- Author:
Zhijie FU
1
;
Xinliang PAN
;
Dapeng LEI
;
Dayu LIU
;
Wenjun LIU
;
Chunxi LIU
;
Rong WANG
;
Ping YE
Author Information
1. Department of Otolaryngology, Qilu Hospital of Shandong University, Jinan, 250012, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Case-Control Studies;
Cyclin D1;
metabolism;
Cyclin-Dependent Kinase Inhibitor p16;
metabolism;
Female;
Humans;
Hypopharyngeal Neoplasms;
metabolism;
pathology;
Lymphatic Metastasis;
Male;
Middle Aged;
Prognosis
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(9):406-409
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expressions of Cyclin D1 and p16 proteins in hypopharyngeal squamous cell carcinoma and their clinical significance.
METHOD:Immunohistochemical technology (P-V) was applied to detect the expression of Cyclin D1 and p16 in 36 cases of hypopharyngeal squamous cell carcinoma and 10 cases of normal epithelium.
RESULT:(1) The expression of cyclin D1 in the tumorous cell was significantly higher than that in normal epithelium (P < 0.05). The expression of p16 in the tumorous cell was significantly lower than that in normal epithelium (P < 0.05); (2) The positive rate of Cyclin D1 was significantly correlated with clinical stage and cervical lymph node metastases (P < 0.05). The positive rate of p16 was correlated with cervical lymph node metastases (P < 0.05). The positive rates of Cyclin D1 and p16 were not correlated with the gender, age, tumor size, primary lesion and cell differentiation (P > 0.05); (3) There was correlation between the expression of Cyclin D1 and the expression of p16 (r(s) = -0.420, P < 0.05).
CONCLUSION:The over-expression of Cyclin D1 and the under-expression of p16 may play a significant role in the occurrence incidence and development of hypopharyngeal squamous cell carcinoma, and may be important indicators for cervical lymph node metastases.
