Up-regulation of MUC2 mucin gene in chronic rhinosinusitis.
- Author:
Xuekun HUANG
1
;
Yuan LI
;
Peng LI
;
Hong LIU
;
Qintai YANG
;
Jin YE
;
Weijie XU
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China. xuekunhuang@163.com
- Publication Type:Journal Article
- MeSH:
Adult;
Case-Control Studies;
Female;
Humans;
Male;
Mucin-2;
genetics;
metabolism;
Nasal Mucosa;
metabolism;
Sinusitis;
genetics;
metabolism;
Up-Regulation
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(11):486-488
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of MUC2 in human sinus mucosa and compare the expression of MUC2 mRNAs in normal and in chronic sinus mucosa.
METHOD:Thirty-two chronic ethmoid sinusitis mucosa samples and 8 normal ethmoid sinus mucosa samples were obtained; RNAs were extracted from sinus mucosa, and fluorescent quantitative PCR was performed for MUC2.
RESULT:The levels of MUC2 mRNAs in chronic rhinosinusitis were significantly increased compared with those in normal sinus mucosa.
CONCLUSION:This result suggest that up-regulation of MUC2 in chronic rhinosinusitis may play an important role in the pathogenesis of sinus hypersecretion in chronic rhinosinusitis.
