Apoptosis related genes--Bcl-2, bax and iNOS, expressed in the olfactory epithelium of mice infected with influenza virus.
- Author:
Zhihong CHEN
1
;
Daofeng NI
;
Yang GAO
;
Jiayou LIN
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Peking Union Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Mice;
Mice, Inbred BALB C;
Nitric Oxide Synthase Type II;
metabolism;
Olfactory Mucosa;
metabolism;
Orthomyxoviridae;
Orthomyxoviridae Infections;
metabolism;
Proto-Oncogene Proteins;
metabolism;
Proto-Oncogene Proteins c-bcl-2;
bcl-2-Associated X Protein;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(11):510-512
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of apoptosis related genes, Bcl-2, bax, and iNOS in the olfactory epithelium of mice infected with influenza virus, and to discuss how they regulate apoptosis of the olfactory sensory neurons.
METHOD:The expression levels of apoptosis related genes were detected with semi-quantity RT-PCR.
RESULT:(1) The expression levels of Bcl-2 mRNA remain relatively constant after virus inoculation; (2) The expression levels of bax mRNA increased massively, and decreased gradually; (3) The expression levels of iNOS mRNA increased significantly in a short period, and then fell down to the undetectable level gradually.
CONCLUSION:The apoptosis related genes, Bcl-2, bax, and iNOS may play important roles in regulation of apoptosis of olfactory sensory neurons of mice infected with influenza virus.
