Expression and significance of TGF-beta1 and HSP70 in human laryngeal squamous cell carcinoma.
- Author:
Shuzhi YANG
1
;
Haiyan CHEN
;
Wei ZHANG
;
Dagen LIU
;
Erzhong FAN
;
Ying LI
Author Information
1. Department of Otolaryngology, First Affiliated Hospital of Chinese General Hospital of PLA, Beijing 100037, China. qits-002@163.com
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
HSP70 Heat-Shock Proteins;
metabolism;
Humans;
Immunohistochemistry;
Laryngeal Neoplasms;
metabolism;
pathology;
Male;
Middle Aged;
Neoplasm Staging;
Prognosis;
Transforming Growth Factor beta1;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(12):531-534
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of TGF-beta1 and HSP70 in human laryngeal squamous cell carcinoma.
METHOD:The expression levels of TGF-beta1 and HSP70 in 53 specimens of human laryngeal squamous cell carcinoma and 48 specimens of para-carcinoma were detected by immuno- histochemistry and computer assisted image analysis.
RESULT:The expression of TGF-beta1 was decreased in carcinoma tissues compared with para-carcinoma tissues ( P < 0.05), while the expression of HSP70 was increased ( P < 0.05). Both the expression of TGF-beta1 and HSP70 were significantly correlated with the differentiation of laryngeal squamous cell carcinoma (P < 0.01 or P < 0.05). However, there was a negative correlation between TGF-beta1 and HSP70 (r = -0.87, P < 0.01).
CONCLUSION:TGF-beta1 and HSP70 play an important role in malignant behaviors of human laryngeal carcinoma.
