The expression of FasL and ICAM-1 on the HEVs in the hypertrophic tonsils.
- Author:
Yang LIU
1
;
Zhibin WANG
;
Haijing YU
;
Fang WANG
;
Shenghong LIU
;
Yonghua CUI
Author Information
1. Department of Otorhinolaryngology, Head and Neck Surgery,Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
B-Lymphocytes;
immunology;
Child;
Child, Preschool;
Endothelium;
blood supply;
Fas Ligand Protein;
metabolism;
Female;
Humans;
Hypertrophy;
Intercellular Adhesion Molecule-1;
metabolism;
Male;
Palatine Tonsil;
metabolism;
pathology;
T-Lymphocytes;
immunology;
Tonsillitis;
metabolism;
Venules;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(15):700-702
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of FasL and ICAM-1 on the HEVs in the hypertrophic tonsils and its clinical significance.
METHOD:Under the light microscopy, HE and immunohistochemistry methods were used to show the morphology of HEVs, the number of T, B lymphocytes, the expression intensity of FasL and ICAM-1 in 17 patients with the idiopathic tonsillar hypertrophy (ITH) and in 20 patients with the chronic hypertrophic tonsillitis (CHT).
RESULT:The expression intensity of ICAM-1 on the tonsillar HEVs in ITH group was significantly lower than that in CTH group (P < 0.05), but the intensity of FasL in ITH group was significantly higher than that in CHT group (P < 0.05).
CONCLUSION:FasL and ICAM-1 expression in the tonsillar HEVs contribute to the CHT and ITH. The former mainly makes IHT developed, and the latter promotes the process of the inflammation.
