The expression of MMP-2, E-cadherin in supraglottic carcinoma and their relationship with cervical lymph node metastasis.
- Author:
Changling SUN
1
;
Ding XIN
;
Yan WANG
Author Information
1. Department of Otolaryngology, the Fourth People' s Hospital, Wuxi, 214062, China.
- Publication Type:Journal Article
- MeSH:
Cadherins;
metabolism;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Humans;
Laryngeal Neoplasms;
metabolism;
pathology;
Lymph Nodes;
pathology;
Lymphatic Metastasis;
Male;
Matrix Metalloproteinase 2;
metabolism;
Prognosis
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(18):834-837
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expressions of matrix metalloproteinase-2 (MMP-2) and E-cadherin in laryngeal carcinoma and their relationship with cervical lymph node metastasis.
METHOD:The expression of MMP-2 and E-cadherin in 10 cases of normal laryngeal mucosa and 48 cases of supraglottic carcinoma were detected by immunohistochemistry.
RESULT:The expression of MMP-2 in supraglottic carcinoma was significantly higher than that in normal laryngeal mucosa. The expression of MMP-2 in metastatic lymph nodes was significantly higher than that in nonmetastatic lymph nodes (P < 0.05). The expression of E-cadherin was significantly lower in supraglottic carcinoma than that in normal laryngeal mucosa. The expression of E-cadherin was significantly lower in metastatic lymph nodes than that in nonmetastatic lymph nodes (P < 0.05). There is a negative correlation between the expression of MMP-2 and E-cadherin (r = -0.41). Predicting the lymph node metastasis of laryngeal carcinoma with the index of MMP-2(+), E-cadherin(-) and MMP-2(+), E-cadherin(-). MMP-2(+) has the highest sensitivity, but the lowest specificity and positive predictive value. MMP-2(+), E-cadherin(-) has the highest specificity and positive predictive value, but the lowest sensitivity.
CONCLUSION:Expression of MMP-2 and E-cadherin can be used as a marker to predict lymph node metastasis of supraglottic carcinoma. Combined the detection of MMP-2 and E-cadherin can boost the accuracy of prediction of lymph node metastasis in supraglottic carcinoma and provide efficient assistance for resecting supraglottic carcinoma.
