The expression of serum IL-10,12,13,16 in patients with allergic rhinitis and vasomotor rhinitis.
- Author:
Jianjun CHEN
1
;
Weijia KONG
;
Yue ZHOU
;
Jisheng XIANG
;
Hong SHU
;
Qiumei SHI
;
Huifang TAN
Author Information
1. Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Case-Control Studies;
Child;
Child, Preschool;
Female;
Humans;
Interleukin-10;
blood;
Interleukin-12;
blood;
Interleukin-13;
blood;
Interleukin-16;
blood;
Male;
Middle Aged;
Rhinitis, Allergic, Perennial;
blood;
Rhinitis, Allergic, Seasonal;
blood;
Rhinitis, Vasomotor;
blood;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(20):913-915
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the role of serum IL-10, 12, 13, 16 in patients with allergic rhinitis and vasomotor rhinitis.
METHOD:The serum levels of IL-10, 12, 13, 16 were measured by ELISA in 30 cases of allergic rhinitis, 25 cases of vasomotor rhinitis and 20 healthy people.
RESULT:The level of IL-12 in allergic rhinitis was (170.33 +/- 90.58) ng/L, which was significantly lower than that of normal controls [(376.69 +/- 140.70) ng/L, P < 0.01]. The levels of IL-13 and IL-16 in allergic rhinitis were (408.51 +/- 189.68) ng/L and (151.53 +/- 63.56) ng/L, which were significantly higher than those of normal controls [(151.92 +/- 85.08) ng/L, (60.65 +/- 32.45) ng/L, P < 0.01]. There were no significant difference of levels of IL-10, 13, 16 between vasomotor rhinitis and normal controls, while the level of IL-12 in vasomotor rhinitis was lower than that of normal controls [(196.03 +/- 96.31) ng/L vs. (376.69 +/- 140.70) ng/L, P < 0.01]. It was suggested that IL-10 had positive correlation with IL-12 (r = 0.73, P < 0.01), and IL-13 had positive correlation with IL-16 (r = 0.94, P < 0.01).
CONCLUSION:The imbalance of IL-12, IL-13 and IL-16 play crucial roles of regulation in the onset and developing of allergic rhinitis. Further research is needed on the role of IL-12 in vasomotor rhinitis.
