The expression and significance of integrin beta1 and focal adhesion kinase and its clinical value in laryngeal carcinoma.
- Author:
Guobiao WEI
1
;
Yuxiao DU
;
Chengzhang YANG
;
Xiaomeng ZHANG
Author Information
1. Department of Otolaryngology, the First Affiliated Hospital of Jiaxing Medical College, Jiaxing, 314000, China. w.gb1988@163.com
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Focal Adhesion Kinase 1;
metabolism;
Humans;
Integrin beta1;
metabolism;
Laryngeal Neoplasms;
metabolism;
pathology;
Male;
Middle Aged;
Neoplasm Staging
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(24):1112-1114
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expressions and clinical significance of integrin beta1 and focal adhesion kinase (FAK) in laryngeal carcinoma (LSCC).
METHOD:The mRNA and protein levels of integrin beta1 and focal adhesion kinase and the surrounding tissue of laryngeal carcinoma in 48 specimens and 20 specimens of vocal cord polyp were detected by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry SABC method.
RESULT:The mRNA levels and positive rates of integrin beta1 and FAK protein were significantly higher in laryngeal carcinoma than that in the surrounding tissue and vocal cord polyp (P < 0.05). The expression levels of integrin beta1 and FAK were significantly higher in the group with cervical lymph node metastasis than those without (P < 0.05), and they were significantly higher in the tissue of stage of T3 and T4 than those of T1 and T2 (P < 0.05). But pathological grades was not significantly related with the expression levels of integrin beta1 or FAK (P > 0.05).
CONCLUSION:The expression levels of integrin beta1 and FAK were increased in LSCC, and they may contribute significantly to invasion and metastasis of LSCC.
