Clinical significance of lymph vessel density marked by D2-40 in laryngeal squamous cell carcinomas.
- Author:
Yu SHUANG
1
;
Binquan WANG
;
Shuxin WEN
;
Yongwang HUANG
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Tianjin Medical University, Tianjin, 300211, China. shuangyu618@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Antibodies, Monoclonal;
Carcinoembryonic Antigen;
immunology;
Carcinoma, Squamous Cell;
pathology;
Female;
Humans;
Immunohistochemistry;
methods;
Laryngeal Neoplasms;
pathology;
Lymph Nodes;
pathology;
Lymphangiogenesis;
Lymphatic Metastasis;
Lymphatic Vessels;
pathology;
Male;
Middle Aged
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(3):102-104
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the relationship between lymphatic vessel density and clinicopathological features of laryngeal squamous cell carcinoma.
METHOD:The lymph vessels, 40 specimens of LSCC and normal mucosa, were quantitated by SABC immunohistochemistry staining with lymphatic endothelial marker oncofetal antigen M2A Monoclonal antibody (D2-40).
RESULT:The density of peritumoral D2-40(+) vessels in the LSCC group was higher than that of normal mucosa one (P<0.01). The density of peritumoral D2-40(+) vessels in T3/4 group was higher than that of T1/2 group (P<0.05). The density of peritumoral D2-40(+) vessels in the neck lymph nodal metastasis group was higher than that without neck lymph nodal metastasis group (P<0.05). The density of peritumoral D2-40(+) vessels in the supraglottic group was higher than that of glottic group (P<0.01). The density of peritumoral D2-40(+) vessels among high, middle, poor differentiation group were no significant difference (P>0.05).
CONCLUSION:Tumor lymph vessel mainly means peritumoral lymph vessel. The density of peritumoral lymph vessel marked with D2-40 in laryngeal carcinoma tissues was significantly correlated with progression and invasion of tumor.
