The expression and relationship of cyclooxygenase-2 and latent membrane protein-1 in nasopharyngeal carcinoma.
- Author:
Weiqi BAI
1
;
Jianguo TANG
Author Information
1. Department of Otolaryngology, the Second Hospital of Ningbo City, Ningbo, 315010, China.
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
metabolism;
pathology;
Cyclooxygenase 2;
metabolism;
Female;
Humans;
Lymphatic Metastasis;
Male;
Middle Aged;
Nasal Mucosa;
metabolism;
pathology;
Nasopharyngeal Neoplasms;
metabolism;
pathology;
Neoplasm Staging;
Viral Matrix Proteins;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(3):105-108
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To discuss the expression and correlation of COX2 and LMP1 in NPC.
METHOD:Fifty-three nasopharyngeal biopsy specimens of NPC patients who had been diagnosed definitely with pathology in our department from 2000 to 2005, and 8 nasopharyngeal biopsy specimens of chronic nasopharyngitis patients were collected. The expression of COX2, LMP1 were detected with streptavidin peroxidase immunohistochemistry staining. All the datas were analyzed with SPSS 12.0.
RESULT:The positive expression rate of COX2 was 71.70% (38/53), and that of LMP1 was 66.04% (35/53) of Nasopharyngeal carcinoma tissue. The higher expression rate was detected in neck lymph nodes metastasis group of nasopharyngeal carcinoma (P<0.05). While the expression rate of COX2, LMP1 was no significant relation with age, gender, clinical stage and pathological classification (P>0.05). The expression of COX2 and LMP1 showed positive correlation (gamma = 0.797, P<0.01).
CONCLUSION:COX2 and LMP1 were highly expressed in nasopharyngeal carcinoma cells. The expressions of COX2 and LMP1 was significantly associated with neck lymph nodes metastasis, and was none-significant relation with age, gender, clinical stage and pathological classification. The expression of LMP1 showed a significant positive correlation with that of COX2. LMP1 could enhance NPC neck lymph nodes metastasis by up-regulating the expression of COX2.
