The expression of Galectin-3 and VEGF in laryngeal squamous cell carcinoma.
- Author:
Hong KONG
1
;
Junsheng CUI
;
Lianyou WANG
;
Zhen DONG
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, China. konghong@jlu.edu.cn
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Galectin 3;
metabolism;
Humans;
Laryngeal Neoplasms;
metabolism;
pathology;
Male;
Middle Aged;
Vascular Endothelial Growth Factor A;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(3):109-112
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of galectin-3 and VEGF in laryngeal squamous cell carcinoma (LSCC) tissue and to analyze its role in differentiation, growth and metastasis of the tumor.
METHOD:The expression of galectin-3 and VEGF were detected with SP immunohistochemistry staining and western blot in twenty-nine specimens of LSCC and eighteen specimens of laryngeal benign lesion.
RESULT:The expression of galectin-3 (89.7%) and VEGF (86.2%) in LSCC were remarkably higher than that in normal control tissue (P<0.05), and the expression of galectin-3 (89.7%) and VEGF (86.2%) in higher histodifferentiation specimens were higher than that in lower histodifferentiation specimens (P<0.05). Moreover, the expression level of galectin-3 and VEGF was detected a statistical positive correlation (r=0.423, P<0.05) in LSCC.
CONCLUSION:The high level expression of galectin-3 and VEGF in LSCC could play an important role in tumorous histodifferentiation and metastasis.
