Expression of transforming growth factor beta1 in human vocal fold polyps.
- Author:
Tao LIU
1
;
Ping WU
;
Mingxiu ZHENG
Author Information
1. Department of Otolaryngology, the Second Affiliated Hospital of Kunming Medical College, Kunming, 650101, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Case-Control Studies;
Female;
Humans;
Laryngeal Diseases;
metabolism;
pathology;
Male;
Middle Aged;
Polyps;
metabolism;
pathology;
Transforming Growth Factor beta1;
metabolism;
Vocal Cords;
metabolism;
pathology;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(5):211-213
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the expression of transforming growth factor-beta1 (TGF-beta1) in human vocal fold polyps, and explore the pathogenesis of vocal fold polyp.
METHOD:The expression of TGF-beta1 were detected in 37 examples of vocal fold polyps and 11 healthy vocal folds by immunohistochemical staining (SP method). Meanwhile, the positive results were compared.
RESULT:The percent of positive expression of TGF-beta1 was 56.76% and the number of positive cells was 22.55 +/- 27.31 in vocal fold polyps, both of which were significantly increased compared with the percent of positive expression of TGF-beta1 (18.18%) and the number of positive cells (2.53 +/- 3.75) in healthy vocal folds (P<0.05). The positive expression of TGF-beta1 in stroma cells of vocal cord polyps was significantly higher than that in the healthy vocal cords. There was no significant difference of TGF-beta1 between the vocal fold polyps of male and female (P>0.05).
CONCLUSION:TGF-beta1 may participate in some pathologic changes in vocal cord polyps, such as extracellular matrix accumulation, local fibrosis and formation and development of vocal cord polyps. Manipulating the TGF-beta1 expression in vocal cord polyps may supply a new treatment method.
