Research of cellular toxic effect to Hep-2 of recombinant toxin MSH-Ang.
- Author:
Weiguo ZHOU
1
;
Xin NI
;
Zhigang HUANG
;
Jugao FANG
;
Demin HAN
;
Dongdong ZHU
;
Zhen DONG
;
Zhanquan YANG
Author Information
1. Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University Tongren Hospital, Beijing, 100730, China. zhouweiguosky@sohu.com
- Publication Type:Journal Article
- MeSH:
Angiopoietins;
genetics;
pharmacology;
Cell Line, Tumor;
Genetic Engineering;
Humans;
Laryngeal Neoplasms;
Melanocyte-Stimulating Hormones;
genetics;
pharmacology;
Recombination, Genetic
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(5):225-226
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the cytotoxicity of recombinate toxin MSH-Ang to Hep-2.
METHOD:The depurated MSH-Ang were applied in cytotoxicity experiment, and the growth inhibiting action to laryngeal carcinoma cell Hep-2 were observed.
RESULT:Recombination protein inhibited the growth of laryngeal carcinoma cell Hep-2, and its inhibiting action enhanced and corpuscular mortality rate increased along with the concentration increasing.
CONCLUSION:Recombinant toxin MSH-Ang can not only take special effect in tumors with high MSHR, but also target to many other popular tumors.
