Increase expression of neurotrophins mRNA in peripheral blood of patients with allergic rhinitis.
- Author:
Renhui CHEN
;
Hao WANG
;
Yanqing ZHONG
;
Yiqun GENG
;
Ciyan XU
;
Weibiao KANG
;
Yulong LIN
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Brain-Derived Neurotrophic Factor;
blood;
genetics;
Child;
Female;
Humans;
Male;
Nerve Growth Factor;
blood;
genetics;
Neurotrophin 3;
blood;
genetics;
RNA, Messenger;
genetics;
Rhinitis, Allergic;
blood;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(5):308-310
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To assess the expression of NGF, BDNF, NT-3 mRNA in the peripheral blood of patients with allergic rhinitis (AR). Meanwhile, to analysis whether the expression of NGF, BDNF, NT-3 mRNA correlate with the severity of rhinitis.
METHOD:This study is a group controlled trial, which takes the healthy adults as control group. The total RNA have been extracted from the peripheral blood of AR patients. The expression of NGF, BDNF and NT-3 mRNA have been tested by real-time quantitative RT-PCR.
RESULT:Comparing with the healthy adults, the expression of NGF, BDNF and NT-3 mRNA as 2(-deltadeltaCt) are 2.436 8, 4.4588 and 1.781 8 respectively. The increasing expression of NT-3 correlated positively with the scores of visual analog scale.
CONCLUSION:The expression of NGF, BDNF and NT-3 mRNA are as high as 2.4368, 4.4588 and 1.7818 times to healthy adults. We propose NGF, BDNF and NT-3 may contribute to the pathogenesis of AR. NT-3 could reflect the severity of rhinitis as a molecular biological index.
