Experimental study on H2-Ab1 gene expression in the nasal mucosa of mice with allergic rhinitis.
- Author:
Yu ZHANG
;
Juan FENG
;
Jun YONG
;
Jie SUN
;
Hua ZHANG
- Publication Type:Journal Article
- MeSH:
Animals;
Female;
Gene Expression;
Histocompatibility Antigens Class II;
genetics;
metabolism;
Mice;
Nasal Mucosa;
metabolism;
Rhinitis, Allergic;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(5):327-331
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the level of H2-Ab1 in the nasal mucosa of mice with allergic rhinitis.
METHOD:Twenty-four female 129/sv mice were divided into 2 groups: ovalbumin (OVA) group and control. The allergic rhinitis models were induced by classical method with OVA. After the last challenge, the pathological differences between the two groups were surveyed. The levels of H2-AB1 were measured by ELISA and quantitative real time PCR.
RESULT:The expression of H2-Ab1 is higher in subjects with AR than that in controls (P < 0.05).
CONCLUSION:The levels of H2-Ab1 were highly increased in allergic rhinitis group, which might be associated with the pathogenesis of allergic rhinitis.
