The expression and significance of Dickkopf-1 and GATA-6 in laryngeal carcinoma.
- Author:
Wenhui YUE
;
Ruili ZHAO
;
Tieli YU
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Female;
GATA6 Transcription Factor;
metabolism;
Humans;
Intercellular Signaling Peptides and Proteins;
metabolism;
Laryngeal Neoplasms;
metabolism;
pathology;
Male;
Middle Aged
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(9):643-646
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of Dickkopf-1 and GATA-6 in laryngeal carcinoma and to discuss their relevance and the roles in carcinogenesis and development of laryngeal carcinoma.
METHOD:Immunohistochemical technique was used to detect the expression of Dickkopf-1 and GATA-6 protein in 48 tissues of larynge al carcinoma, 48 para-carcinoma tissues and 20 normal laryngeal mucosal tissues.
RESULT:(1) The expression of Dick kopf-1 protein in laryngeal cancer is significantly lower than in para-carcinoma tissues and normal laryngeal mucosa tissues (P < 0.05). (2) The expression of GATA-6 protein in laryngeal cancer is significantly higher than in para-carcinoma tissues and normal laryngeal mucosa tissues (P < 0.05). (3) The expression of Dickkopf-1 and GATA-6 protein in laryngeal cancer is correlated with lymph node metastasis, clinical stage, histological grade (P < 0.05). (4) The expression of Dickkopf-1 and GATA-6 are negatively correlated in laryngeal cancer.
CONCLUSION:The expression of Dickkopf-1 and GATA-6 may contribute to the carcinogenesis and development of laryngeal carcinoma.
