Expression of TGF-beta1 and collagen fibers in chronic nasal-sinusitis nasal mucosa of patients.
- Author:
Wenjun JI
;
Xin WANG
;
Chunyuan ZHAO
- Publication Type:Journal Article
- MeSH:
Adult;
Case-Control Studies;
Chronic Disease;
Collagen;
metabolism;
Humans;
Middle Aged;
Nasal Mucosa;
metabolism;
Rhinitis;
metabolism;
pathology;
Sinusitis;
metabolism;
pathology;
Transforming Growth Factor beta1;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(11):756-759
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:Explore the TGF-beta1 and collagen fibers in chronic nasal sinusitis each type and degree of expression of the normal control group and in the nasal mucosa epithelial tissue remodeling and the role of TGF-beta1 and collagen deposition relationship.
METHOD:Sixty-two patients experimental group (CRSwNP of 21 cases. CRSs NP group of 15 cases. 11 cases of recurrent nasal polyps; control group 15 cases specimens for immunohistochemistry and masson collagen staining. Manual counting the number of positive cells by the Mann-Whitney U test to analyze the expression in experimental group and the control group. Experimental group and control group between the single-factor analysis of variance with a One-Way ANOVA analysis.
RESULT:Experimental group and control group were expressed TGF-beta1 with collagen deposition. Which, TGF-beta1 in CRSsNP group was significantly lower than the control group (P < 0.05), CRSwNP group was significantly increased compared with CRSsNP group (P < 0.05); masson collagen staining, CRSsNP group was significantly lower than the control group (P < 0.01), recurrent nasal polyps group than in the control group was significantly increased (P < 0.05). TGF-beta1 and collagen staining masson positive correlation between (P < 0.01 ).
CONCLUSION:TGF-beta1 and collagen deposi tion and chronic nasal-sinusitis tissue remodeling has its relevance. Furthermore. TGF-beta1 expression increased with excessive deposition of collagen fibers also positively correlated.
