Analysis of HLA-DQB1 polymorphism for patients with allergic rhinitis of Uygur and Han people in Xinjiang.
- Author:
Zhongtao CUI
1
;
Hua ZHANG
;
Yunlian LIU
;
Yuping YANG
;
Yangbing XIANG
Author Information
1. Department of Otolaryngology, First Hospital Affiliated Xinjiang Medical University, Urumqi 830063, China. hzhang1106@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Alleles;
Asian Continental Ancestry Group;
genetics;
Case-Control Studies;
Ethnic Groups;
Female;
Gene Frequency;
HLA-DQ beta-Chains;
genetics;
Humans;
Male;
Middle Aged;
Polymorphism, Genetic;
Rhinitis, Allergic, Seasonal;
genetics;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(14):645-648
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the association of HLA-DQB1 alleles and artemisia pollen allergic patients of Han and Uygur people in the Xinjiang area.
METHOD:PCR-SSP (sequence-specific primer polymerase chain reaction) were used to test fifty Uygur and fifty Han people with allergic rhinitis with hypersensitivity to artemisia pollen in the Xinjiang area. Fifty normal Uygur and fifty normal Han people in the Xinjiang region were enrolled in the control group.
RESULT:The frequency of HLA-DQB1 * 05 in the Uygur group with allergic rhinitis was significantly higher (19.4%) than that in the Uygur control group (7%) (P < 0.05). There were no significant difference between in the allergic rhinitis group and in the control group.
CONCLUSION:HLA-DQB1 * 05 might be the susceptibility genes of the Uygur patients with allergic rhinitis in the Xinjiang area.
