Effect of topical steroid on oral and nasal nitric oxide production in patients with allergic rhinitis.
- Author:
Qian GAO
1
;
Yuan ZHANG
;
Chengshuo WANG
;
Yan ZHAO
;
Luo ZHANG
Author Information
1. Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing,100730, China.
- Publication Type:Journal Article
- MeSH:
Administration, Intranasal;
Adolescent;
Adult;
Anti-Allergic Agents;
administration & dosage;
therapeutic use;
Female;
Humans;
Male;
Middle Aged;
Mometasone Furoate;
Nitric Oxide;
metabolism;
Pregnadienediols;
administration & dosage;
therapeutic use;
Quality of Life;
Rhinitis, Allergic, Perennial;
drug therapy;
metabolism;
physiopathology;
Rhinitis, Allergic, Seasonal;
drug therapy;
metabolism;
physiopathology;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(20):913-919
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the effects of nasal mometasone furoate on oral and nasal nitric oxide (NO) production in patients with allergic rhinitis.
METHOD:Twenty-seven patients with moderate to severe symptoms of persistent allergic rhinitis were treated with mometasone furoate nasal spray (200 microg/d. qd) for 2 weeks. Nasal and oral exhaled nitric oxide concentrations, symptoms of rhinitis and quality of life were investigated before and after the treatment.
RESULT:There was a significant improvement in nasal exhaled nitric oxide concentrations, symptoms of rhinitis and quality of life, but not in oral exhaled nitric oxide concentrations. Subjective improvements in symptoms and quality of life did not correlate significantly with objective measurements.
CONCLUSION:Our study provides subjective and objective evidence on the efficacy of intranasal mometasone furoate in improving nasal symptoms and quality of life, as well as reducing nasal inflammation.
