The expression and its potentially clinical significance of EphA2 in nasopharyngeal carcinoma.
- Author:
Guochen ZHU
1
;
Dajiang XIAO
;
Qi CHEN
;
Yawei ZHU
Author Information
1. Department of Otolaryngology, the Second Affiliated People's Hospital of Wuxi, Nanjing Medical University, Wuxi, 214002, China. zgc2003doctor@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Carcinoma;
Female;
Humans;
Lymphatic Metastasis;
Male;
Microvessels;
Middle Aged;
Nasopharyngeal Carcinoma;
Nasopharyngeal Neoplasms;
blood supply;
metabolism;
pathology;
Neoplasm Staging;
Neovascularization, Pathologic;
pathology;
Prognosis;
Receptor, EphA2;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(18):827-833
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the expression of EphA2, and investigate its correlation with the development, progression, invasion, metastasis, angiogenesis and prognosis in nasopharyngeal carcinoma(NPC).
METHOD:Immunohistochemical staining was used to determine the expression level of EphA2 protein in 61 cases NPC and 20 cases chronic nasopharyngitis samples. The clinically pathological data and results of follow-up were collected. Microvessel density (MVD) was also measured by immunohistochemical staining method with CD34 in NPC.
RESULT:The positive rate of EphA2 protein staining in NPC was 60.66% (37/61), while that in nasopharyngitis samples was 10.0% (2/20). The positive rates of EphA2 protein in NPC were 27.27% (3/11) in stage I, 56.25% (9/16) in stage II, 68.19% (15/22) in stage III, and 83.33% (10/12) in stage IV. The positive expressions of EphA2 in T1 + T2 and T3 + T4 with neck lymph node and distant metastasis were 58.33% (7/12) and 88.89% (16/18) respectively, while those in T1 +T2 and T3 + T4 without metastasis were 31.25% (5/16) and 50.00% (6/12) respectively. The cumulative survival of patients in the EphA2 positive group at 5 years was only 0.324 (12/37), while 0.500 (12/24) in the EphA2 negative group. The positive expression of EphA2 protein was correlated with the clinical stage, the neck lymph node metastasis and distant metastasis, and prognosis of NPC, respectively (P < 0.05). MVD in EphA2 protein positive group (45.32 +/- 4.91) was significantly higher than that in EphA2 protein negative group (28.69 +/- 3.99, P < 0.01).
CONCLUSION:EphA2 may play an important role in the development and progression of NPC. It is closely associated with the invasion, metastasis, angiogenesis and prognosis of NPC.
