Expression of MEF2D on nasopharyngeal carcinoma tissues and its influence of prognostic.
- Author:
Yongling LI
1
;
Longcheng ZHANG
;
Jiang NONG
;
Shixia BIAN
;
Zhen ZHAO
;
Yi REN
;
Xinran LIN
;
Xiuwu BIAN
Author Information
1. Department of Otolaryngology, No. 303 Hospital of PLA, Nanning, China, 530021.
- Publication Type:Journal Article
- MeSH:
Adult;
Carcinoma;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Humans;
Lymphatic Metastasis;
MADS Domain Proteins;
metabolism;
MEF2 Transcription Factors;
Male;
Middle Aged;
Myogenic Regulatory Factors;
metabolism;
Nasopharyngeal Carcinoma;
Nasopharyngeal Neoplasms;
metabolism;
pathology;
Neoplasm Staging;
Prognosis
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(18):840-847
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the expression of MEF2D in NPC tissues, study the relationship between the expression and prognostic.
METHOD:Specimens from 101 NPC patients who were follow-up visited 1 to 7 years were analyzed for MEF2D by using immunohistochemistry.
RESULT:(1) The expression of MEF2D was higher in the higher clinical stage. (2) Density and Grey of MEF2D was negative correlated (|r| = 0.865, P < 0.01). (3) NPC patients' survival rate after therapies was 52.5%, the survival curve of 1th clinical stage was higher than 4th. (4) The survival curves of MEF2D stages were no statistical significance.
CONCLUSION:There's statistical significance of the MEF2D expression in clinical stages, but not in survival curve, which indicated that MEF2D concerned with invasion and metastatic of NPC.
