Study of expression and significance of DSCR1 gene in laryngopharynx cancer and peri-cancerous tissues.
- Author:
Chao LÜ
1
;
Xinliang PAN
;
Ju GAO
;
Zhen LI
Author Information
1. Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Ji' nan, 250012, China.
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
genetics;
pathology;
Female;
Gene Expression;
Humans;
Hypopharynx;
pathology;
Intracellular Signaling Peptides and Proteins;
genetics;
Laryngeal Neoplasms;
genetics;
pathology;
Male;
Middle Aged;
Muscle Proteins;
genetics;
Neoplasm Staging
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(18):848-850
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expressions of DSCR1 gene in laryngopharynx cancer and peri-cancerous tissues, to understand the relationship between its expression and tumor clinical features, to discussed the influence of DSCR1 gene on the biological behaviours of laryngopharynx squamous cell carcinoma.
METHOD:Immunohistochemical p-V9000 method,used rabbit DSCR1 antibody DCT3, detected the expressions of DSCR1 gene protein in laryngopharynx cancer and peri-cancerous tissues, between them and clinical data were statistically analyzed.
RESULT:Positive rates of DSCR1 gene expression in the tumor tissues was 94.9%, normal tissues was 35.9%, there was a statistically significant (t = 23.69, P < 0.01); There was significant difference of DSCR1 gene expressions in different pathological degree and TNM staging (P < 0.05). There was no significant difference in different age, gender, site, growth mode, lymph node metastasis and smoking history.
CONCLUSION:DSCR1 gene has an important role in the occurrence and development process of laryngopharynx squamous cell carcinoma, and can influence the biological behavior of tumors.
