Clinical significances of serum NO and oxLDL in obstructive sleep apnea-hypopnea syndrome.
- Author:
Guangfeng JIANG
1
;
Jinhui ZHANG
;
Wei LI
Author Information
1. Department of Otorhinolaryngology, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China. qdsleep@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adult;
Case-Control Studies;
Female;
Humans;
Lipoproteins, LDL;
blood;
Male;
Middle Aged;
Nitric Oxide;
blood;
Serum;
chemistry;
Sleep Apnea, Obstructive;
blood;
physiopathology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(21):974-976
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the correlation between the serum levels of nitrogen oxide (NO) and oxidized low density lipoprotein (oxLDL) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).
METHOD:NO and oxLDL levels were measured in 60 OSAHS patients and 26 healthy subjects. OSAHS patients were divided into mild, moderate and severe groups according to AHI.
RESULT:NO levels in the moderate and sever OSAHS groups was significantly lower than that in the control group, but the levels of oxLDL was increased compared with the control group. (P < 0.05). The serum levels of NO was negatively correlated with AHI (P < 0.01) and positively correlated with the lowest SaO2 (P < 0.01), the serum levels of oxLDL was positively correlated with AHI (P < 0.01) and negatively correlated with the lowest SaO2 (P < 0.01), NO levels showed negative correlations with oxLDL levels (P < 0.01).
CONCLUSION:The serum level of NO is reduced in response to the increase of AHI and the acceleration of hypoxia, which indicated that there is a correlation between vascular endothelial dysfunction and the severity of hypoxia. The decrease of the level of NO and the increase of the oxLDL can promote the formation of atherosclerosis, which increased the incidence of cardiocerebrovascular disease in patients with OSAHS.
