The expression of MMP-2, -9 in the uterine leiomyoma and its significance in prognosis.
- Author:
Yan ZHENG
1
;
Chunli WANG
;
Jun DING
;
Shoushan JIAO
;
Fengzhi SI
;
Liming QU
;
Hui BAO
Author Information
1. Department of Otolaryngology, the Second Hospital Affiliated Xinjiang Medical University, Urumqi, 830063, China. zy91900@sina.com
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
diagnosis;
metabolism;
pathology;
Female;
Humans;
Lymphatic Metastasis;
Matrix Metalloproteinase 2;
metabolism;
Matrix Metalloproteinase 9;
metabolism;
Prognosis;
Uterine Neoplasms;
diagnosis;
metabolism;
pathology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(22):1037-1039
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study on the expression and significance of MMP-2 and MMP-9 in the nasus epithelial carcinoma and their signification.
METHOD:Fifty cases of epithelial carcinoma tissue and 50 cases of normal nasus tissue were detected for MMP-2 and 9 by immunohistochemistry technique (SP), and analysed their relationships between expression of MMP-and some clinical symptoms.
RESULT:The positive ratio of expression of MMP-2 in 50 cases of epithelial carcinoma was 52.0% (26/50), which was significantly higher than those in the normal nasus tissue 28.0% (14/50), P < 0.05. The positive ratio of expression of MMP-9 in 50 cases of epithelial carcinoma was 58.0% (29/50), which was significantly higher than those in the normal nasus tissue 10.0% (5/50), P < 0.05.
CONCLUSION:It was suggested that there was a close relationship between pathogenesis and development of nasus epithelial carcinoma and the expression of MMP-2, MMP-9 in the epithelial carcinoma tissues. The positive results of MMP-2, MMP-9 is partly valid for diagnosis of prognosis rate of MMP-2 and MMP-9 expression was high in nasus epithelial carcinoma tissues, MMP-2 and MMP-9 expression levels might be able to provide prognostic information.
