Expressions of LL-37 and IL-8 in chronic sinusitis with nasal polyps.
- Author:
Dan XIE
1
;
Yunkai GUO
;
Dan WU
;
Dinghua XIE
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Antimicrobial Cationic Peptides;
Cathelicidins;
metabolism;
Chronic Disease;
Female;
Humans;
Interleukin-8;
metabolism;
Male;
Middle Aged;
Nasal Mucosa;
metabolism;
Nasal Polyps;
metabolism;
Sinusitis;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(8):337-340
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expressions of LL-37 and IL-8 in chronic sinusitis with nasal polyps.
METHOD:Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemical staining were used to detect the expressions of LL-37 and IL-8 in nasal polyp tissues of 31 patients with chronic sinusitis and inferior turbinate tissues of 11 patients with chronic rhinitis.
RESULT:LL-37 and IL-8 mRNA were all positively expressed in all nasal polyps and inferior turbinate tissues. There were significant increases of LL-37 and IL-8 mRNA expressions in nasal polyps compared with the inferior turbinate tissues (P < 0.01). There were also significant increases of positive expression rates of LL-37 and IL-8 protein in nasal polyps, compared with the inferior turbinate tissues (P < 0.01). There was a positive relationship between the mRNA and protein expressions of LL37 and IL-8 (P < 0.01).
CONCLUSION:The expressions of LL-37 and IL-8 in nasal polyps suggest that they may play a role in the pathogenesis of chronic sinusitis. Besides its innate immune, LL-37 could enhance human body's anti-infected function by increasing acquired immune.
