The expression of IL-23 in nasal mucosa of allergic rhinitis patients and its significance.
- Author:
Yang LIU
1
;
Zheng LIU
;
Xiang LU
;
Qixue GAO
;
Yonghua CUI
Author Information
1. Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Case-Control Studies;
Female;
Humans;
Inflammation;
immunology;
Interleukin-23;
immunology;
Male;
Middle Aged;
Nasal Mucosa;
immunology;
metabolism;
Rhinitis, Allergic, Perennial;
immunology;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(14):638-640
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of interleukin (IL)-23 in the nasal mucosa of allergic rhinitis patients and its significance.
METHOD:mRNA and protein expression of IL-23 in inferior turbinate mucosa from 12 allergic rhinitis patients and 11 control patients was measured by means of real-time RT-PCR and immunohistochemistry, respectively.
RESULT:IL-23p19 mRNA relative expression level in nasal mucosa was significantly increased in allergic rhinitis patients compared with normal controls (P < 0.01). Immunohistochemical staining demonstrated that IL-23 protein was mainly expressed by infiltrating inflammatory cells in lamina propria and there was increased number of IL-23 positive cells in allergic rhinitis patients in comparison with normal controls. Correlation analysis showed that the mRNA and protein expression level of IL-23 was significantly positively correlated with the number of the inflammatory cells (r = 0.678 and 0.644, respectively; both P < 0.01) and the degree of subepithelial collagen deposition (r = 0.834 and 0.721, respectively; both P < 0.01). IL-23p19 mRNA relative expression level in nasal mucosa was significantly decreased in allergic rhinitis patients who used glucocorticoids compared with controls (P < 0.01).
CONCLUSION:IL-23 may contribute to the chronic inflammation and airway remodelling in allergic rhinitis.
