The dynamic expression of the TGF-beta1 and FGF-2 in the nasal mucosa in the allergic rhinitis rat models.
- Author:
Bingbin XIE
1
;
Yuehui LIU
;
Gui LUO
;
Jianguo LIU
;
Yanping ZHONG
;
Xiaofeng MEI
Author Information
1. Department of Otorhinolaryngology, Foshan Hospital of Traditional Medicine, Foshan, 528000, China. linyun02@hotmail.com
- Publication Type:Journal Article
- MeSH:
Animals;
Female;
Fibroblast Growth Factor 2;
metabolism;
Male;
Nasal Mucosa;
metabolism;
pathology;
Rats;
Rats, Sprague-Dawley;
Rhinitis, Allergic, Perennial;
metabolism;
pathology;
Transforming Growth Factor beta1;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(14):655-658
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the dynamic expression of the TGF-beta1 and FGF-2 in the nasal mucosa of rat models of allergic rhinitis, at different stages of the process during pathogenesis.
METHOD:One hundred and eighty Sprague-Dawley (SD) rats were randomly divided into three groups, the normal Group A used for contrast and experimental groups: Group B and C, each group were 60 rats. Then, observed the expression of the TGF-beta1 and FGF-2 in the nasal mucosa at different stages of the process by immunohistochemical staining.
RESULT:The expression of the TGF-beta1 and FGF-2 in the nasal mucosa of the normal Group A was negative, while the Group B and Group C were varying degrees of positive both, and Group B, the level of the TGF-beta1 and FGF-2 were both decline after allergen avoidance, but still more not ability than the expression of the Group B (P < 0.05).
CONCLUSION:The expression of the TGF-beta1 and FGF-2 in the nasal mucosa of rats models were varying degrees of positive , and it is decline while the allergen avoidance.
