Significance of Oct-4's expression in thyroid neoplasm.
- Author:
Haiwei WANG
1
;
Jiadong WANG
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, Renji Hospital, Institute of Otorhinolaryngology, School of Medicine, Shanghai Jiaotong University, Shanghai, 200001, China.
- Publication Type:Journal Article
- MeSH:
Adenocarcinoma, Follicular;
metabolism;
pathology;
Carcinoma, Neuroendocrine;
Carcinoma, Papillary;
metabolism;
pathology;
Humans;
Octamer Transcription Factor-3;
metabolism;
Thyroid Neoplasms;
metabolism;
pathology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(15):682-685
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To discuss the meanings of Oct-4's expression in thyroid adenoma, thyroid papillary carcinoma, thyroid follicular carcinoma, and medullary thyroid carcinoma.
METHOD:We examined the expression of Oct-4 in 15 thyroid adenoma, 30 thyroid papillary carcinomas, 2 thyroid follicular carcinomas, and 3 medullary thyroid carcinomas using immunofluorescence.
RESULT:Oct-4 expression was observed in all the thyroid-related diseases mentioned above. In thyroid papillary carcinomas, the expression of Oct-4 were higher than that in thyroid adenoma, and had no obvious relationship with the patients age, sex, the size and location of tumor and tumor metastasis.
CONCLUSION:The formation of the thyroid carcinomas may be concerned with the stem cells in thyroid. There are more stem cells in medullary thyroid carcinomas and follicular carcinomas.
