Expression of SSTR2 and P-STAT3 in human olfactory neuroblastoma.
- Author:
Ming ZENG
1
;
Yonghua CUI
;
Cuihuan WU
Author Information
1. Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Esthesioneuroblastoma, Olfactory;
metabolism;
pathology;
Female;
Humans;
Male;
Middle Aged;
Nose Neoplasms;
metabolism;
pathology;
Receptors, Somatostatin;
metabolism;
STAT3 Transcription Factor;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(15):690-692
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect the expression and relationship between somatostatin receptor 2 (SSTR2) and phosphorylated STAT3 (P-STAT3) in human olfactory neuroblastoma (ONB) and adjacent normal olfactory nerve tissue.
METHOD:Immunohistochemical (IHC) staining was used to detect the expression of SSTR2 and P-STAT3 in tumor and adjacent normal olfactory nerve tissue from 11 ONB patients.
RESULT:SSTR2 was mainly expressed in cell cytoplasm and the expression intensity was significantly stronger in tumor tissues than in adjacent normal tissues (P<0.01). P-STAT3 was mainly expressed in cell nuclear in tumor tissues. No expression was found in adjacent normal tissues. There was a negative correlation between the expression intensity of SSTR2 and P-STAT3 (r(s) = -0.367, P<0.05).
CONCLUSION:Lower expression of SSTR2 and activation of STAT3 in ONB cells might contribute to the development of ONB.
