Expression of PCNA, BCL-2, CD4+, CD8+ in the adenoid tissues from children with secretory otitis media.
- Author:
Shujun ZHANG
1
;
Yuli ZHANG
;
Zhuoli YUE
;
Guiru YIN
;
Yingchun WANG
;
Qinghong LI
Author Information
1. Department of Otolaryngology, the Affiliated Hospital to Chengde Medical College, Chengde, 067000, China.
- Publication Type:Journal Article
- MeSH:
Adenoids;
immunology;
metabolism;
CD4-Positive T-Lymphocytes;
immunology;
CD8-Positive T-Lymphocytes;
immunology;
Child;
Child, Preschool;
Female;
Humans;
Male;
Otitis Media with Effusion;
immunology;
metabolism;
Proliferating Cell Nuclear Antigen;
metabolism;
Proto-Oncogene Proteins c-bcl-2;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(16):740-742
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship between immune status of adenoids and secretory otitis media (SOM).
METHOD:The adenoid tissue samples of 72 cases with SOM and 30 cases with adenoid hypertrophy without SOM were studied by immunohistochemical method.
RESULT:The PCNA, BCL-2, CD4+, CD8+ and CD4+ / CD8+ in SOM tissue samples were 30.85 +/- 1.73, 21.27 +/- 1.25, 41.90 +/- 9.07, 20.45 +/- 7.08 and 2.10 +/- 0.17, respectively, which were much more than that of tissue samples without SOM (25.25 +/- 1.75, 14.05 +/- 1.02, 16.30 +/- 8.21, 11.15 +/- 5.71, 1.39 +/- 0.15 respectively) (P < 0.01). The expression of CD4+ in T-lymphocyte was obviously higher than that of CD8+.
CONCLUSION:In adenoid tissues of SOM patients, the activity of T-lymphocyte subsets are increased,the adenoids are enlarged and local immunity are enhanced. Therefore,adenoidectomy should be applied in SOM patients as early as possible.
