Effect of topical corticosteroids on expression of PKC, Bcl-2 and Bax in nasal polyps.
- Author:
Xiumin REN
1
;
Yanzhong YANG
;
Naichao DUAN
;
Xinxia JIANG
;
Qiang HE
Author Information
1. Department of Otorhinolaryngology, the Second Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050000, China. rxm1966@sina.com
- Publication Type:Journal Article
- MeSH:
Administration, Intranasal;
Adolescent;
Adult;
Aged;
Female;
Glucocorticoids;
pharmacology;
therapeutic use;
Humans;
Male;
Middle Aged;
Nasal Polyps;
drug therapy;
metabolism;
Protein Kinase C;
metabolism;
Proto-Oncogene Proteins c-bcl-2;
metabolism;
Young Adult;
bcl-2-Associated X Protein;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(17):772-775
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of intranasal glucosteroid on the expression of PKC, Bcl-2 and Bax in nasal polyps.
METHOD:The expression of PKC, Bcl-2 protein and Bax were detected with immunohistochemistry in nasal polyps from the patients (n=16) pre and post treated for 4 weeks with intranasal glucosteroid. And which compared with normal mucous membrane of inferior turbinate concha.
RESULT:The PKC and Bcl-2 protein expressed significantly higher in the pretreated patients (P < 0.01), which were significant reduced in the post treated patients compared with pretreated ones. The expression of Bax protein significantly higher in the post treated patients (P < 0.05).
CONCLUSION:Our findings indicated that abnormal expression of apoptosis related genes in nasal polyps tissues might play an important role in the occurrence and progression of nasal polyps. The treatment of intranasal glucosteroid may regulate the expression of apoptosis related genes.
