Estrogen receptor-β expression in laryngeal carcinoma: correlation with the expression of epithelial-mesenchymal transition specific biomarkers.
- Author:
Lan MU
;
Jingcheng GU
;
Yongchao ZHANG
;
Yan LIANG
;
Chuan WANG
;
Wang LI
- Publication Type:Journal Article
- MeSH:
Antigens, CD;
Biomarkers, Tumor;
metabolism;
Cadherins;
metabolism;
Epithelial-Mesenchymal Transition;
Estrogen Receptor beta;
metabolism;
Humans;
Immunohistochemistry;
Laryngeal Neoplasms;
metabolism;
Lymphatic Metastasis;
beta Catenin;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(10):921-924
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect the expression of ERβ in laryngeal carcinoma and the its correlation with the expression of epithelial-mesenchymal transition(EMT) specific biomarkers.
METHOD:Picture MT-Pv9000 was used to detect ERβ and EMT in 72 cases of human aqueous laryngeal carcinoma and 8 cases of adjacent non-neoplastic laryngeal mucosa by immunohistochemistry.
RESULT:The positive rates of ERβ in tumors and adjacent non-neoplastic laryngeal mucosa were 27.78% and 25.00%, respectively. The differences were not significant (P > 0.05). The abnormal expression rates of E-cadherin and β-catenin were 61.11% and 76.39% respectively. The expression of ERβ correlated negatively with the loss of E-cadherin, nuclear translocation of β-catenin and increased TNM stage. The differences were significant (P < 0.05).
CONCLUSION:The positive expressions of ERβ suggest a good prognosis in the differentiation, clinical stages and lymphatic metastasis of the laryngeal carcinoma. The underlying mechanism may be related with the abnormal expressions of E-cadherin and β-catenin.
