Expressions and correlations of Survivin, Ki67 and p53 in laryngeal squmous cell carcinoma.
- Author:
Jvxiang WANG
;
Baoliang YANG
;
Shigeng PEI
;
Xueling WANG
;
Qingjun ZHANG
;
Feng QU
;
Hong ZHANG
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
metabolism;
Humans;
Immunohistochemistry;
Inhibitor of Apoptosis Proteins;
metabolism;
Ki-67 Antigen;
metabolism;
Laryngeal Neoplasms;
metabolism;
Larynx;
Lymphatic Metastasis;
Polyps;
metabolism;
Survivin;
Tumor Suppressor Protein p53;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(17):1545-1548
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of Survivin, p53 and Ki67 in laryngeal carcinoma and the relation with clinical data.
METHOD:Immunohistochemical staining (SP) was used to detect expression of Survivin, p53 and Ki67 of 64 cases with laryngeal carcinoma, 26 cases with precancerosis, 34 cases with vocal polyps.
RESULT:The positive expression rates of Survivin, p53 and Ki67 were 59.4%, 68.8%, 65.6% respectively in laryngeal carcinoma, which were significantly higher than those in precancerosis and vocal polyps (P < 0.01). The expression of Survivin, p53 and Ki67 in laryngeal carcinoma were significantly statistical different in TNM stage and lymph node metastasis (P < 0.05), but were not correlated with patients' ages, the pathological grades, 3 years and 5 years surviving rates (P > 0.05). The expression of Survivin, Ki-67 and p53 was positively correlated (r = 0.607, 0.541, 0.648, P < 0.01) in laryngeal carcinoma.
CONCLUSION:Survivin, p53 and Ki-67 may play an important role in the carcinogenesis and progress of laryngeal carcinoma. They may play synergetic roles in the process of carcinogenesis of laryngeal carcinoma.
