Research on radiation sensitization effect of microRNA and clinical perspectives in nasopharyngeal carcinoma.
- Author:
Teng HUANG
;
Li YIN
;
Jing WU
- Publication Type:Journal Article
- MeSH:
3' Untranslated Regions;
Carcinoma;
Humans;
MicroRNAs;
pharmacology;
Nasopharyngeal Carcinoma;
Nasopharyngeal Neoplasms;
drug therapy;
radiotherapy;
RNA, Messenger;
Radiation Tolerance;
Radiation-Sensitizing Agents
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(17):1574-1576
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy is the primary treatment for nasopharyngeal carcinoma, and the disease control rate and survival time are able to be greatly improved by enhancing the radiosensitivity. Via mechanisms such as binding to target genes mRNA 3'untranslated region (3'UTR), microRNA (miRNA) inhibits translation, which therefore regulates transcription of target genes and thus affect target protein expression. Recent research showed that miRNAs play significant roles in improvement of radiosensitivity in nasopharyngeal carcinoma. This article reviews mechanism of miRNA action to strengthen radiosensitivity of nasopharyngeal carcinoma and the future of clinical practice of miRNA in this disease.
