Expression of BTG1 protein in laryngeal squamous cell carcinoma and its clinical significance.
- Author:
Runxue JIANG
;
Wanning HU
;
Guogui SUN
;
Jiangong WANG
;
Xiaochen HAN
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
metabolism;
pathology;
Head and Neck Neoplasms;
metabolism;
pathology;
Humans;
Immunohistochemistry;
Laryngeal Mucosa;
metabolism;
Laryngeal Neoplasms;
metabolism;
pathology;
Lymphatic Metastasis;
Neoplasm Grading;
Neoplasm Proteins;
metabolism;
Neoplasm Staging;
Prognosis;
Squamous Cell Carcinoma of Head and Neck
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(16):1447-1450
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of B-cell translocation gene 1 (BTG1) and to determine the relationship between BTG1 expression and clinicopathological features, biological behaviors in laryngeal squamous cell carcinoma.
METHOD:Immunohistochemistry and Western blot were used to analyze BTG1 protein expression in 70 cases of laryngeal cancer and 35 cases of adjacent corresponding laryngeal mucosal tissues to illuminate the relationship between BTG1 expression and clinical factors.
RESULT:The positive rate of BTG1 protein expression was 31.43% in laryngeal carcinoma tissues, significantly lower than 91.43% in the adjacent laryngeal tissues (P < 0.05). Western blot showed the relative expression of BTG1 protein between cancer lesion and adjacent tissue were 0.217 ± 0.032 and 0.918 ± 0.081, showing the difference with statistical significance (P < 0.05). The expression of protein was significantly correlated with the tumor invasion, lymph node metastasis, clinic stage and histological grade (P < 0.05 or P < 0.01), but not with sex, age and tumor location (P > 0.05) of patients with laryngeal cancer.
CONCLUSION:The expression of BTG1 protein was decreased in laryngeal squamous cell carcinoma, suggesting that BTG1 gene may be closely associated with the carcinogenesis and the degree of malignancy. Detection of BTG1 expression may be useful in diagnosis, treatment and prognosis of laryngeal carcinoma.
