Expression of phosphofructokinase 1 protein and it's enzyme activity on nasopharyngeal carcinoma.
- Author:
Shuo LI
;
Haiyu HONG
;
Zhengde DU
;
Fei LIU
;
Qiong YANG
;
Chunsheng GAO
- Publication Type:Journal Article
- MeSH:
Biomarkers, Tumor;
metabolism;
Biopsy;
Carcinoma;
Case-Control Studies;
Humans;
Lymphatic Metastasis;
Nasopharyngeal Carcinoma;
Nasopharyngeal Neoplasms;
enzymology;
pathology;
Nasopharyngitis;
Phosphofructokinase-1;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(16):1455-1457
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:The aim of this study is to investigate the expression of phosphofructokinase 1 and it's enzyme activity in nasopharyngeal carcinoma biopsy samples.
METHOD:Sixty-one biopsy samples were detected, including 41 tissues from patients with nasopharyngeal carcinoma as experimental group and 20 tissues from patients with chronic nasopharyngitis as control group. Phosphofructokinase 1 protein was detected by Western blot and it's enzyme activity was detected.
RESULT:It was observed that the expression levels of phosphofructokinase 1 protein and it's enzyme activities in the experimental group were higher than that in the control group (P < 0.01). In the experimental group, the expression levels of phosphofructokinase 1 protein and it's enzyme activities in patients with lymph node metastasis were higher than that in patients without lymph node metastasis (P < 0.01).
CONCLUSION:Phosphofructokinase 1 may be a marker in occurrence and metastasis of nasopharyngeal carcinoma.
