Expression and significance of C/EBPα and CK10 in nasal inverted papilloma.
- Author:
Yibing YAUN
;
Xianying MENG
;
Xu WU
- Publication Type:Journal Article
- MeSH:
CCAAT-Enhancer-Binding Proteins;
genetics;
metabolism;
Humans;
Keratin-10;
genetics;
metabolism;
Nasal Polyps;
genetics;
metabolism;
Neoplasm Recurrence, Local;
Nose;
Nose Neoplasms;
genetics;
metabolism;
Papilloma, Inverted;
genetics;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(5):437-440
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:The expression of C/EBPα, CK10 in nasal inverted papilloma (NIP) were detected in the study. Further discussed their significance in genesia, development and recurrence of NIP.
METHOD:Three groups including nasal cavity mucosae (NM 10 cases), nasal polyp (NP 20 cases) and NIP (30 cases) were selected in the study. Expretion of C/EBPα, CK10 were detected by immunohistochemisty PV-6000 method.
RESULT:(1) The different expression of C/EBPα and CK10 in the group of NM, NP and NIP was statistically significant (P < 0.05). (2) The different expression of C/EBPα, CK10 in the group of benign NIP and NIP with atypical hyperplasia was statistically significant (P < 0.05). (3) The different expression of C/EBPα and CK10 in the group of NIP with recurrence and NIP with no recurrence was statistically significant, P < 0.05, respectively. (4) Our result indicate that the relationship of C/EBPα and CK10 (r = 0.578, P < 0.01) was direct correlation. The difference was statistically significant.
CONCLUSION:In conclusion, the present results describe C/EBPα, CK10 expression in NIP and their possible implication in the regulation of tumor growth and differentiation. C/EBPα and CK10 production may prove useful in terms of a prognostic marker for the recurrence in nasal inverted papilloma.
