Meta-analysis on autogenous fat injection for unilateral vocal cord paralysis.
- Author:
Qingqing XU
;
Suoqiang ZHAI
;
Rongguang WANG
;
Shiming YANG
;
Dongyan HUANG
- Publication Type:Journal Article
- MeSH:
Adipose Tissue;
transplantation;
Humans;
Injections;
Treatment Outcome;
Vocal Cord Paralysis;
therapy;
Voice Quality
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(7):625-629
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:This study conduct a qualitative synthesis and quantitative meta-analysis of VFAFI, aimed to study whether it is a useful treatment for UVCP.
METHOD:Electronic databases PubMed, YZ365. COM, WANFANG DATA, CMJD, CHKD,CNKI were searched using relevant keywords. Reported treatment outcomes were clustered into three categories,i. e. subjective, perceptual,acoustic,aerodynamic,and stroboscopic. Meta-analyses were performed on studies with numerical results using random effects model.
RESULT:Five articles were identified with a total of 404 patients. All the studies reported significant improvements or decrease after VFAFI in each category of outcome measurements. Meta-analysis demonstrated a significant increase or decrease in all categories. Adverse effects include slight inflammatory reponse can resolve spontaneously within 1 month. The recurrence rate after VFAFI was high due to the self absorption. NNE and Jitter of post-operation is lower than pre-operation,there is no significantly change between the control group and experimental group; F0, Shimmer and MPT of post-operation is higher than pre-operation, there is no significantly change between the control group and experimental group.
CONCLUSION:The invasiveness and morbidity of VFAFI are low and the side effects are self-limited. Meta-analyses demonstrated significant improvements or decreased from both objective and subjective measurements. Further controlled studies with longer follow-up periods and more person were included may evaluate the effectiveness of VFAFI more reliably.
