The expression and significance of programmed cell death 5 and Bcelllymphoma/lewkmia-2 in sinonasal squamous cell carcinoma.
- Author:
Honglue LU
;
Chengshuo WANG
;
Lingling HAO
;
Guiru YIN
;
Ran HAO
- Publication Type:Journal Article
- MeSH:
Apoptosis Regulatory Proteins;
metabolism;
Carcinoma, Squamous Cell;
metabolism;
mortality;
Head and Neck Neoplasms;
metabolism;
mortality;
Humans;
Neoplasm Proteins;
metabolism;
Papilloma, Inverted;
metabolism;
Paranasal Sinus Neoplasms;
metabolism;
Proto-Oncogene Proteins c-bcl-2;
metabolism;
Squamous Cell Carcinoma of Head and Neck;
Survival Rate
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(17):1301-1304
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the expression and significance of programmed cell death 5 (PDCD5) and Bcelllymphoma/lewkmia-2(Bcl-2) in sinonasal squamous cell carcinoma (SNSCC).
METHOD:Immunohistochemical method and Western Blot method was used to determine the expression of PDCD5 and Bcl-2 in specimen of SNSCC in thirty cases, sinonasal inverted papillomas (SNIP) in thirty-eight cases, and normal nasal mucosa in twenty cases.
RESULT:(1) The expression of PDCD5 protein in SNSCC significantly decreased compared with SNIP and normal nasal mucosa. (2) The expression of Bcl-2 protein in SNSCC up-regulated obviously compared with SNIP and normal nasal mucosa. (3) Positive rate of PDCD5 protein and Bcl-2 protein in well, moderate and low differentiatied group is respectively 100.00%, 83.33%, 38.89% and 50.00%, 70.83% and 100.00%, the difference was statistically significant (P < 0.05). (4) In the follow-up cases, the survival rate of the patients with higher expression of PDCD5 protein was higher, but that with lower expression of Bcl-2 protein was higher.
CONCLUSION:The inactivation of PDCD5 protein and the activation of Bcl-2 protein may play an important role in the development of SNSCC, and there are a positive correlation between PDCD5 and Bcl-2 protein in SNSCC, which may be identified as a new therapeutic target.
