Distribution change of mast cells in human nasal polyps.
- Author:
Guimin ZHANG
;
Wenjie SHI
;
Peiyong SUN
;
Peng LIN
- Publication Type:Journal Article
- MeSH:
Chemokine CCL11;
metabolism;
Chemokine CCL5;
metabolism;
Chemokine CX3CL1;
metabolism;
Epithelial Cells;
metabolism;
Humans;
Immunohistochemistry;
Interleukin-6;
metabolism;
Interleukin-8;
metabolism;
Mast Cells;
metabolism;
pathology;
Nasal Mucosa;
cytology;
metabolism;
Nasal Polyps;
metabolism;
pathology;
Up-Regulation
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(17):1337-1340
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the distribution of mast cells in nasal polyps.
METHOD:Biopsy specimens from patients with nasal polyps (n = 20) and control patients (n = 8) were obtained and included in this study. The distribution of mast cells in nasal polyps and the expression of chemokines (CCL5, CCL11, CX3CL1, IL-8, IL-6) in the epithelial cells of normal nasal mucosa and nasal polyps was determined by immunohistochemistry.
RESULT:Mast cells migrate to intraepithelial in nasal polyps and the expression of chemokines (CCL5, CCL11, CX3CL1, IL-8) was up regulated in the epithelial cells of nasal polyps compare to normal nasal mucosa.
CONCLUSION:Our findings showed that mast cells migrate to intraepithelial in nasal polyps and the over expression of chemotaxins (CCL5, CCL11, CX3CL1, IL-8) may be response for mast cells' migration in nasal polyps. Mast cells might be associated with the development of nasal polyps.
