Expression and significance of DNA-dependent protein kinase in human laryngeal squamous cell carcinoma.
- Author:
Jiansong SUN
;
Xiuhai YANG
;
Hongpei JI
;
Rui ZHAO
;
Yubing DAI
- Publication Type:Journal Article
- MeSH:
Aged;
Carcinoma, Squamous Cell;
enzymology;
pathology;
DNA-Activated Protein Kinase;
metabolism;
Female;
Head and Neck Neoplasms;
enzymology;
pathology;
Humans;
Laryngeal Mucosa;
enzymology;
Laryngeal Neoplasms;
enzymology;
pathology;
Larynx;
enzymology;
Lymph Nodes;
Lymphatic Metastasis;
Male;
Middle Aged;
Squamous Cell Carcinoma of Head and Neck
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(21):1641-1644
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of DNA-dependent protein kinase (DNA-PK) in human laryngeal squamous cell carcinoma (LSCC) and normal laryngeal mucosa (NLM), and to analysize the relationship between the expression and the clinicopathologic parameters of LSCC.
METHOD:Immunohistochemical technique (Envision) was used to detect the expression of DNA-PK in 64 cases of LSCC and 15 cases of NLM. To investigate an investigation was conducted on the relationship between the expression and clinico-pathological features of LSCC.
RESULT:DNA-PK was lowly expressed in NLM and highly expressed in LSCC,the positive rate of DNA-PK expression was 26.67% (4/15), 78.13% (50/64), respectively, and there was significant different difference between the two groups (P < 0.05). Its expression was correlated with the level of histodifferentiation (P < 0.05), but not with TNM stages and neck lymph node metastasis (P > 0.05).
CONCLUSION:DNA-PK may be involved in disease development of LSCC.
