Haplotype analysis of XRCC3 gene and laryngeal.
- Author:
Xu ZHOU
;
Ying QI
- Publication Type:Journal Article
- MeSH:
Case-Control Studies;
DNA-Binding Proteins;
genetics;
Genotype;
Haplotypes;
Humans;
Laryngeal Neoplasms;
genetics;
Polymorphism, Single Nucleotide
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(21):1655-1657
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the association of XRCC3 gene polymorphisms and haplotypes with laryngeal.
METHOD:We selected 4 tag SNPs (rs12432907, rs861536, rs861537, rs861531, rs861531) for the present study. 310 laryngeal patients and 310 healthy control subject were genotyping. The distribution of genotypes and haplotypes in these two group was compared.
RESULT:The distributions of rs12432907 was significantly different between these two groups. The CCAG haplotype frequency was higher in laryngeal group than that in control group. But TCAG and TTAG haplotype frequency was were lower in the laryngeal patient than that those in the control subject.
CONCLUSION:XRCC3 gene polymorphism was associated with the risk of laryngeal patients.
