Meta-analysis of association between MMP-1-1607 polymorphism and head and neck cancer risk in asia population.
- Author:
Xiangjun CHEN
;
Zizhong YU
;
Yuankun GAO
;
Guolei LIU
;
Lei TIAN
;
Guoyi LI
- Publication Type:Journal Article
- MeSH:
Asia;
Asian Continental Ancestry Group;
Case-Control Studies;
Genotype;
Head and Neck Neoplasms;
enzymology;
ethnology;
genetics;
Humans;
Matrix Metalloproteinase 1;
genetics;
Polymorphism, Single Nucleotide;
Promoter Regions, Genetic
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(21):1679-1684
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze and explore the association between the 1607(1G/2G) single nucleotide polymorphism (SNP) in promoter of matrix metalloproteinase-1 (MMP-1) gene and susceptibility of head and neck cancer (HNC) by Meta-analysis.
METHOD:By the end of January 2014, the published literatures were collected for the case-control studies evaluating the relationship between HNC and -1607 SNP of MMP-1 gene from English and Chinese literature databases according to the inclusion and exclusion criteria. Then the meta-analysis, the heterogeneity, bias and sensitivity of the results of the eligible literatures were conducted by Stata 10. 0.
RESULT:A total of 9 studies including 2049 patients with HNC and 2158 controls were extracted for systematic review on the association of MMP-1 (-1607) 1G/2G SNP with the risk of HNC. Meta-analysis which based on random effects model showed that MMP-1 (-1607) 1G/2G SNP can significantly increase the risk of HNC[1G2G + 2G2G vs. 1G1G: OR = 1.45, 95% CI 1.25-1.68, P < 0.01; 2G2G vs. 1G1G + 1G2G:OR = 1.77, 95% CI 1.37-2.30, P < 0.01; 2G vs. 1G: OR = 1.52, 95% CI 1.26-1.85, P < 0.01; 2G2G vs. 1G1G: OR = 2.06, 95% CI 1.41-3.01, P < 0.01).
CONCLUSION:MMP-1 (-1607) 1G/2G SNP has close relationship with HNC susceptibility, people who with 2G2G genotype carriers are susceptible to HNC.
