Effect of Mitomycin C on Rabbit Corneal Wound Healing after Excimer Laser Photorefractive Keratectomy.
- Author:
Jae Hyuk LEE
1
;
Jae Hong AHN
;
Ho Min LEW
;
Dong Ho LEE
Author Information
1. Department of ophthalmology, Ajou University College of Medicine, Korea. chrisahn@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Eximer laser phtorefractive keratectomy;
Mitomycin C
- MeSH:
Corneal Opacity;
Endothelial Cells;
Endothelium;
Epithelium, Corneal;
Lasers, Excimer*;
Mitomycin*;
Photorefractive Keratectomy*;
Postoperative Period;
Preoperative Period;
Rabbits;
Wound Healing*;
Wounds and Injuries*
- From:Journal of the Korean Ophthalmological Society
2003;44(12):2876-2884
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We investigated the effect of Mitomycin C (MMC) on corneal wound healing after excimer laser photorefractive keratectomy (PRK) in rabbits. METHODS: Excimer laser PRK was performed on 11 white rabbits. Right eyes underwent intraoperative application of 0.02% MMC (MMC group) and left eyes underwent intraoperative application of BSS (control group) for 2 minutes. Corneal opacity was described with slit-lamp biomicroscope at 1, 2, 3, and 4 weeks after PRK. Endothelial cell count and corneal thickness were measured at preoperative period and postoperative 3 weeks. RESULTS: Subepithelial opacity was grade 2 in MMC group and control group at postoperative 1 week. Subepithelial opacity was grade 2 in 1 of 10 eyes of MMC group and was also grade 2 in 8 of 10 eyes of control group at postoperative 2 weeks. Epithelial healing was delayed in MMC group. Corneal thickness showed no relevant difference in MMC group and control group between preoperative and postoperative periods. Endothelial cell count decreased in postoperative period in MMC group while endothelial cell count showed no relevant difference in control group between preoperative and postoperative periods. CONCLUSIONS: The application of 0.02% MMC after PRK for 2 minutes reduced corneal haze. However, delayed healing of corneal epithelium and damage of endothelium can be induced if MMC is not washed thoroughly.
