Clinical significance of miRNA-204 in nasopharyngeal carcinoma.
- Author:
Tao PENG
;
Xuhong ZHOU
;
Min HU
;
Tingting WU
- Publication Type:Journal Article
- MeSH:
Carcinoma;
Disease Progression;
Down-Regulation;
Humans;
Lymphatic Metastasis;
MicroRNAs;
metabolism;
Nasopharyngeal Carcinoma;
Nasopharyngeal Neoplasms;
metabolism;
Nasopharynx;
Prognosis;
Real-Time Polymerase Chain Reaction
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(22):1780-1782
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of miRNA-204 in patients with NPC and to analyze the as- sociation of the expression with the cIinicopathologicaI features and prognosis.
METHOD:The expression levels of miRNA-204 in 50 patients with NPC and 40 patients with nasopharyngeal chronic inflammation were detected by using stem-loop real-time reverse transcription-polymerase chain reaction RT-PCR. Analysis of the relationship between microRNA and prognosis by Kaplan-Meier method.
RESULT:Expression levels of miRNA-204 were down- regulated in patients with NPC as compared with patients with nasopharyngeal chronic inflammation (P < 0.05). The expression of miRNA-204 was associated with EBV infection, differentiation, lymphatic metastasis and TNM stages (P < 0.05). Low miRNA-204 expression was significantly correlated with shorter overall survival (P < 0.05) of NPC.
CONCLUSION:The downregulation of miRNA-204 expression has related with disease progression and miRNA-204 can serve as a potential therapeutic target for NPC.
