Study on the correlation of IgE and GM-CSF contents with eosinophil accumulation in nasal polyp.
- Author:
Congzhe TIAN
1
;
Yanli TAN
;
Yongping GAO
;
Jinduo DU
Author Information
1. Department of Otolaryngology, Affiliated Hospital of Hebei University, Baoding, 071000, China. yongyong5752@vip.sina.com
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Eosinophils;
pathology;
Female;
Granulocyte-Macrophage Colony-Stimulating Factor;
metabolism;
Humans;
Immunoglobulin E;
metabolism;
Male;
Middle Aged;
Nasal Mucosa;
metabolism;
pathology;
Nasal Polyps;
metabolism;
pathology;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(20):916-918
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of IgE, GM-CSF on eosinophil accumulation in the nasal polyps and find the relationship between them.
METHOD:Thirty mucosa constitution samples of nasal polyps and eleven inferior nasal concha were observed. The distribution of IgE was detected by SP immunohistochemical method, while the concentration of GM-CSF was measured by ELISA technique and the number of eosinophils were counted in the same tissues.
RESULT:The level of IgE, GM-CSF and eosinophils had significant different between the nasal polyps and control group (P < 0.01). There was positive correlation between IgE/GM-CSF and the number of eosinophils in the nasal polyps group (r = 0.65, 0.62, P < 0.01). The correlation between concentration of IgE and GM-CSF was also significant in nasal polyps group (r = 0.52, P < 0.01).
CONCLUSION:Nasal polyps is characterized by eosinophil accumulation. IgE and GM-CSF may contribute to the recruitment of eosinophils in nasal polyps. Type-I allergy mediated by IgE play an important role in the pathogenesis of nasal polyps.
