Relationship between GATA-3 and IL-12 in patients with allergic rhinitis.
- Author:
Jun YAO
1
;
Hui ZHOU
;
Mei XU
;
Yuefei ZHANG
Author Information
1. Department of Otolaryngology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, China. Christyhui@126.com
- Publication Type:Journal Article
- MeSH:
Case-Control Studies;
GATA3 Transcription Factor;
metabolism;
Humans;
Interleukin-12;
metabolism;
Nasal Mucosa;
metabolism;
Rhinitis, Allergic, Perennial;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(23):1087-1089
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the relationship between GATA-3 and IL-12 in patients with allergic rhinitis.
METHOD:The expression of GATA-3 was detected by reverse transcriptase polymerase chain reaction (RT-PCR) in 37 patients with allergic rhinitis and 12 control samples. IL-12 was detected by enzyme-linked immunosorbent assay.
RESULT:The relative density ratio of GATA-3 to GAPDH in AR patients was 0.579 +/- 0.102, and in control group was 0.128 +/- 0.021. The concentrations of IL-12 were (53.7 +/- 12.3) ng/g and (121.9 +/- 20.4) ng/g in the two groups respectively. The expression of GATA-3 was negatively correlated to the expression of IL-12 in patients with allergic rhinitis.
CONCLUSION:The overexpression of GATA-3 in patients with allergic rhinitis was related to the decrease of IL-12, and to increasing the expression of IL-12 in topical tissue could suppress the expression of GATA-3 and may improve the therapeutic effectiveness of AR.
