Expressions of matrix metalloproteinase-9 and interleukin-8 in nasopharyngeal carcinoma and association with Epstein-Barr virus latent membrane protein-1.
- Author:
Zhaoyang CAI
1
;
Jianguo TANG
;
Xuan LI
;
Xiaoyou CHEN
;
Zhengbiao YING
;
Yangli ZHU
Author Information
1. Department of Otolaryngology, First Hospital of Wenling City, Wenling, 317500, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Female;
Humans;
Interleukin-8;
metabolism;
Lymphatic Metastasis;
Male;
Matrix Metalloproteinase 9;
metabolism;
Middle Aged;
Nasopharyngeal Neoplasms;
metabolism;
pathology;
Neck;
Prognosis;
Viral Matrix Proteins;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(21):966-969
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expressions of matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8) in nasopharyngeal carcinoma and their association with Epstein-Barr virus latent membrane protein-1 (LMP-1).
METHOD:The expressions of MMP-9, IL-8 and LMP-1 were immunohistochemical studied in 53 nasopharyngeal carcinoma sections. We statistically analyzed the correlation of these data and also the relationship between the clinical features and the experimental data of these patients.
RESULT:The positive expression rate of MMP-9, IL-8 and LMP-1 were all 66.04% (35/53) and their average expression score were (33.19 +/- 29.73)%, (33.46 +/- 30.23)%, (35.49 +/- 29.63)% respectively. The expressions of MMP-9 and IL-8 both showed positive correlation with the expression of LMP-1 (r = 0.792, 0.786 respectively). The expressions of MMP-9, IL-8 and LMP-1 showed significant relationship with lymph nodes metastasis (P < 0.05), but no-significant association with age, gender, pathological classification, and clinical stage.
CONCLUSION:The expressions of MMP-9, IL-8 and LMP-1 were significantly associated with neck lymph nodes metastasis in nasopharyngeal carcinoma. The correlation between LMP-1 and MMP-9, IL-8 showed LMP-1 might enhance neck lymph nodes metastasis by up-regulating the expressions of MMP-9 and IL-8.
