Effects of intranasal budesonide on the expression of c-fos and c-myc in nasal polyps.
- Author:
Hai LIN
1
;
Xianming CHEN
;
Zenian ZHEN
;
Yinghao YU
;
Xisheng XIONG
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Fuzhou General Hospital of Nanjing Command of the PLA, Fuzhou, 350025, China. linh96@163.com
- Publication Type:Journal Article
- MeSH:
Adult;
Budesonide;
administration & dosage;
therapeutic use;
Case-Control Studies;
Female;
Glucocorticoids;
therapeutic use;
Humans;
Male;
Nasal Polyps;
drug therapy;
metabolism;
Proto-Oncogene Proteins c-fos;
metabolism;
Proto-Oncogene Proteins c-myc;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(2):55-57
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of intranasal glucocorticoids treatment on the expression of c-fos and c-myc nasal polyps.
METHOD:Immunohistochemistry method was used to determine c-fos and c-myc expression in nasal polyps from patients with topical steroids treatment for 10-12 weeks and untreated patients.
RESULT:The rate of c-fos expressing cases was 15% and the rate of c-myc expressing cases was 20% in nasal polyps from topical steroid treated patients, but in untreated patients, the rate of c-fos expressing cases was 80% and the rate of c-myc expressing cases was 85%. There were significant differences between two groups (P < 0.01). The c-fos and c-myc expression was remarkably downregulated in nasal polyps from topical steroid treated patients compared to untreated patients.
CONCLUSION:The results show that glucocorticoids may induce cell apoptosis in nasal polyps by depressing the c-fos and c-myc expression.
